Abstract:The outbreak of Ebola in West Africa clearly indicates the important role of city and world city network in the emergence and spreading of infectious diseases. Modern city itself has been continuously shaped by the public health. Nowadays，with the rapid urbanization，new infectious disease not only emerges but also spread in an unprecedented pace. Three reasons can be listed：the intersection and overlapping of human and animal habitat which carry new types of diseases，the mutation enhanced；Urbanization clearly changes the traditional urban-rural interaction；big city especially metropolitan cities become the spreading center，and the overall situation of prevention and control deeply related with position of global city in the world city network. When city dealing with infectious diseases，there is a standard pattern，namely prevention，preparation，response，recovery，but individual living habits play an increasingly important role. Considering the social condition and economic inequality during disease outbreak，some policy intervention is necessary. Policy intervention should be based on the data gathering，coordination between governments，private corporations and civil organizations，or various partnerships. It is needed to point that poor and disadvantaged people always stay in house，community of low-quality or Slum which does not have any health service delivery system，thus how to guarantee the supply of primary health service should seriously taken into consideration.
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